Journal article
Momentary manifestations of negative symptoms as predictors of clinical outcomes in people at high risk for psychosis: Experience sampling study
I Paetzold, KSFM Hermans, A Schick, B Nelson, E Velthorst, F Schirmbeck, J van Os, C Morgan, M van der Gaag, L de Haan, L Valmaggia, P McGuire, M Kempton, I Myin-Germeys, U Reininghaus
Jmir Mental Health | JMIR PUBLICATIONS, INC | Published : 2021
DOI: 10.2196/30309
Open access
Abstract
Background: Negative symptoms occur in individuals at ultrahigh risk (UHR) for psychosis. Although there is evidence that observer ratings of negative symptoms are associated with level of functioning, the predictive value of subjective experience in daily life for individuals at UHR has not been studied yet. Objective: This study therefore aims to investigate the predictive value of momentary manifestations of negative symptoms for clinical outcomes in individuals at UHR. Methods: Experience sampling methodology was used to measure momentary manifestations of negative symptoms (blunted affective experience, lack of social drive, anhedonia, and social anhedonia) in the daily lives of 79 indi..
View full abstractGrants
Awarded by Beatrice and Samuel A. Seaver Foundation
Funding Acknowledgements
The authors sincerely thank the participants and all researchers involved in the data collection. This work was supported by a Postdoctoral Research Fellowship of the UK National Institute for Health Research (UR, NIHR-PDF-201104065); a Heisenberg professorship from the German Research Foundation (UR, grant no. 389624707); financial support from the National Institute for Health Research (NIHR) Biomedical Research Centre for Mental Health at South London and Maudsley NHS Foundation Trust and King's College London; a FWO (Flemish Science Foundation) Odysseus grant (IM-G, G0F8416N); a NHMRC Senior Research Fellowship (BN, 1137687); the Beatrice and Samuel A Seaver Foundation (EV); and the Wellcome Trust (CM, WT087417). This work is an approved add-on study of the "The European Network of National Schizophrenia Networks studying Gene-Environment Interactions " (EU-GEI), which is supported by funding from the European Union (European Community's Seventh Framework Program [HEALTH-F2-2009-241909; Project EU-GEI]).